Adjuvant Therapies for Dysembryoplastic Neuroepithelial Tumors in Children

Medical

  • Seizure medication: Antiepileptic medication can sometimes be gradually withdrawn in consultation with an epileptologist.
  • No chemotherapy: Chemotherapy is not used to treat these tumors.

Radiation

  • Not indicated after complete resection: A general consensus exists that radiotherapy is not needed after surgical resection. The risk of recurrence after complete or subtotal resection is small. There is no proven benefit for adjuvant therapy, and the short- and long-term toxicities must be considered in these patients with a very long life expectancy. Similarly, there is no evidence for management with biopsy and radiotherapy in lesions in eloquent brain regions. Radiation has even been suspected to play a role in the rare cases of malignant transformation (31, 35).
  • Some use after surgery for recurrence: In cases of recurrence, radiotherapy after second surgery is advocated by some authors but is of unproven benefit.

Immunotherapy

  • Not used: There are no data on immunotherapy for DNETs.