Antibiotic Choices for Infecting Organisms of Shunt Infections in Children

This page was last updated on May 9th, 2017

                   Agents for Parenteral Antibiotic Treatment of CSF Shunt Infections

Isolated Microorganism First-line antibiotics Other choices
Staphylococcus epidermidis Vancomycin, linezolid Oxacillin, nafcillin
Staphylococcus aureus Vancomycin, linezolid Oxacillin, nafcillin
Enterococcus faecalis Vancomycin, penicillin Ampicillin
Escherichia coli Cefotaxime, meropenem Gentamycin, amikacin
Klebsiella pneumoniae Cefotaxime, meropenem Gentamycin, amikacin
Proteus sp. Cefotaxime, ceftazidime Gentamycin, amikacin
Pseudomonas sp. Ceftazidime + amikacin Meropenem, cefipime
Haemophilus influenzae Cefotaxime, ampicillin Ceftriaxone
Streptococcus pneumoniae Penicillin G, cefotaxime, ceftriaxone Vancomycin, ampicillin
Neisseria meningitidis Penicillin G, ampicillin Cefotaxime, ceftriaxone
Propionibacterium acnes Penicillin G Doxycycline
Corynebacterium sp. Penicillin G Doxycycline
Candida sp. Amphotericin B Caspofungine, voriconazole


                         Agents for Intraventricular Treatment of CSF Shunt Infections

Antimicrobial Agent Dose
Gentamycin 2–8 mg/day
Vancomycin 4–20 mg/day
Amphotericin B 0.1–0.5 mg/day
Miconazole 20 mg/day

Modified from Kaufman (89)