A syndrome that is rare and involves multiple organ systems. PHACE is an acronym standing for pathological findings or involved organ systems: P = Posterior fossa brain abnormalities; H = Hemangiomas of the face or scalp (large); A = cervical or cerebral Artery abnormalities; C = Cardiac anomalies and Coarctation of the aorta; and E = Eye abnormalities. S can be included in the acronym (PHACES) in which case it stands for Sternal anomalies.